CYTOKINES IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA

被引:1
作者
FOA, R
TOS, AG
DICELLE, PF
CARBONE, A
MARCHIS, D
VISCHIA, F
CIGNETTI, A
GUARINI, A
机构
[1] Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica
关键词
CYTOKINES; B-CLL; LYMPHOCYTIC LEUKEMIA;
D O I
10.3109/10428199109103372
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The pleomorphic action of different cytokines in regulating the growth and proliferation of normal B- and T-lymphocyte populations is becoming progressively more apparent. Thus, the possibility that some cytokines, either alone or in variable combination, may play a role in different lymphoproliferative disorders has been increasingly suggested and potential autocrine or paracrine loops hypothesized. Here, we shall discuss some of the known B-cell growth factors which have been postulated to be involved in the hematological progression, clinical course and complications in B-cell lymphocytic leukemia. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:7 / 11
页数:5
相关论文
共 23 条
[1]  
Foa R., Fierro M.T., Giovarelli M., Lusso P., Benetton G., Bonferroni M., Forni G., Immunoregulatory T-cell defects in B-cell chronic lymphocytic leukemia: cause or consequence of the disease? The contributory role of decreased availability of interleukin 2 (IL-2), Blood Cells., 12, pp. 399-442, (1987)
[2]  
Ayanlar-Batuman O., Ebert E., Hauptman S.P., Defective interleukin-2 production and responsiveness by T cells in patients with chronic lymphocytic leukemia of B cell variety, Blood, 67, pp. 279-284, (1986)
[3]  
Foa R., Giovarelli M., Jemma C., Fierro M.T., Lusso P., Ferrando M.L., Lauria F., Forni G., Interleukin 2 (IL2) and interferon-γ production by T lymphocytes from patients with B-chronic lymphocytic leukemia: evidence that normally released IL2 is absorbed by the neoplastic B cell population, Blood, 66, pp. 614-619, (1985)
[4]  
Alvareze de Mon M., Casas J., Laguna R., Toribio M.L., De Landazuri M.O., Durantez A., Lymphokine induction of NK-like cytotoxicity in T cells from B-CLL, Blood, 67, pp. 228-232, (1986)
[5]  
Platsoucas C.D., Fernandes G., Gupta S.L., Kempin S., Clarkson B., Good R.A., Gupta S., Defective spontaneous and antibody-dependent cytotoxicity mediated by E-rosette-positive and E-rosette-negative cells in untreated patients with chronic lymphocytic leukemia. Augmentation by in vitro treatment with interferon, Journal of Immunology, 125, pp. 1216-1223, (1980)
[6]  
Foa R., Lauria F., Lusso P., Giubellino M.C., Fierro M.T., Ferrando M.L., Raspadori D., Matera L., Discrepancy between phenotypic and functional features of natural killer T-lymphocytes in B-cell chronic lymphocytic leukemia, British Journal of Haematology, 58, pp. 509-516, (1984)
[7]  
Lantz O., Grillot-Courvalin C., Schmitt C., Fermand J.-P., Brouet J.-C., Interleukin 2-induced proliferation of leukemic human B cells, Journal of Experimental Medicine, 161, pp. 1225-1230, (1985)
[8]  
Giovarelli M., Foa R., Benetton G., Lusso P., Fierro M.T., Forni G., Release of interleukin-2-like material by B-chronic lymphocytic leukemia cells. An autocrine or paracrine model of production and utilization?, Leukemia Research, 12, pp. 201-209, (1988)
[9]  
Foa R., Giovarelli M., Fierro M.T., Bonferroni M., Forni G., Autocrine or paracrine models of cytokine production and utilization in B-cell chronic lymphocytic leukemia, Nouvelle Revue Francaise d’Hematologie, 30, pp. 339-341, (1988)
[10]  
Foa R., Fierro M.T., Raspadori D., Bonferroni M., Cardona S., Guarini A., Gillio Tos A., Francia di Celle P., Cesano A., Matera L., Lauria F., Gavosto F., Lymphokine activated killer (LAK) cell activity in B and T chronic lymphoid leukemia: defective LAK generation and reduced susceptibility of the leukemic cells to allogenic and autologous LAK effectors, Blood, 76, pp. 1349-1354, (1990)