MUTATION WITHIN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE CONFERRING RESISTANCE TO (R)-9-(3,4-DIHYDROXYBUTYL)GUANINE

被引：6

作者：

CHIOU, HC ^{[1
]}

KERNS, KM ^{[1
]}

COEN, DM ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1986年 / 30卷 / 03期

关键词：

D O I：

10.1128/AAC.30.3.502

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

引用

页码：502 / 504

页数：3

共 16 条

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[2] MUTATIONS IN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE CONFERRING HYPERSENSITIVITY TO APHIDICOLIN [J].

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[4] MUTATIONS IN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE CAN CONFER RESISTANCE TO 9-BETA-D-ARABINOFURANOSYLADENINE [J].

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[5] FINE MAPPING AND MOLECULAR-CLONING OF MUTATIONS IN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE LOCUS [J].

COEN, DM ;

ASCHMAN, DP ;

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[6]

COEN DM, 1984, UCLA S MOL CELLULAR, V21, P373

[7] RESISTANCE OF HERPES-SIMPLEX VIRUS TO ADENINE-ARABINOSIDE AND E-5-(2-BROMOVINYL)-2'-DEOXYURIDINE - A PHYSICAL ANALYSIS [J].

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SCHNIPPER, LE ;

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JOURNAL OF INFECTIOUS DISEASES, 1982, 146 (02) :167-172

[8] ANTIHERPES EFFECTS AND PHARMACOKINETIC PROPERTIES OF 9-(4-HYDROXYBUTYL)GUANINE AND THE (R) AND (S) ENANTIOMERS OF 9-(3,4-DIHYDROXYBUTYL)GUANINE [J].

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (05) :753-759

[9] HERPES-SIMPLEX VIRUS MUTANTS RESISTANT TO ARABINOSYLADENINE IN THE PRESENCE OF DEOXYCOFORMYCIN [J].

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COEN, DM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 26 (03) :382-387

[10] SEQUENCE AND MAPPING ANALYSES OF THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE PREDICT A C-TERMINAL SUBSTRATE BINDING DOMAIN [J].

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (23) :7969-7973

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