ASSOCIATION OF PATENCY OF THE INFARCT-RELATED CORONARY-ARTERY WITH PLASMA-LEVELS OF PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY IN ACUTE MYOCARDIAL-INFARCTION

To examine the fibrinolytic capacity in patients with acute myocardial infarction (AMI), baseline levels of plasma plasminogen activator inhibitor (PAI) activity and tissue-type plasminogen activator (t-PA) antigen were measured in 47 patients with Q-wave AMI who underwent emergent coronary angiography 3.0 +/- 0.2 hours after the symptom onset. They received intracoronary injection of urokinase if their infarct-related arteries were occluded. They were classified into 3 groups according to the patency of the infarct-related artery before and after thrombolytic therapy: the patent group (13 patients), the recanalized group (23 patients) and the occluded group (11 patients). The mean level of plasma PAI activity (IU/ml) was higher in patients with AMI as a whole than in the control group (12.8 +/- 1.6 vs 5.4 +/- 0.5, p <0.01). The level was lower in the patent group (3.0 +/- 1.1) and higher in the recanalized (18.6 +/- 2.2) and occluded (10.8 +/- 2.5) groups than in the control group (each p <0.01). The level was lower in the occluded than in the recanalized group (p <0.01) and 62% of the patients in the occluded group had levels within range of the control group. The mean level of plasma t-PA antigen (ng/ml) was higher in patients with AMI as a whole than in the control group (10.3 +/- 0.8 vs 5.8 +/- 0.3, p <0.01). There was no difference in the level among the 3 groups with AMI. Thus, this study indicates that there is a significant relation between the baseline plasma fibrinolytic capacity and the patency of the infarct-related artery before and after thrombolytic therapy.