CYTOKINE-RELATED IMMUNOPOTENTIATING ACTIVITIES OF PARAMYLON, A BETA-(1-]3)-D-GLUCAN FROM EUGLENA-GRACILIS

被引：57

作者：

KONDO, Y ^{[1
]}

KATO, A ^{[1
]}

HOJO, H ^{[1
]}

NOZOE, S ^{[1
]}

TAKEUCHI, M ^{[1
]}

OCHI, K ^{[1
]}

机构：

[1] NIKKEN FOODS CO LTD, FUKUROI, SHIZUOKA 43701, JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1992年 / 15卷 / 11期

关键词：

PARAMYLON; BETA-(1-]3)-D-GLUCAN; PLAQUE-FORMING CELL; ADJUVANT; CYTOKINE; INTERLEUKIN-1; INTERLEUKIN-6;

D O I：

10.1248/bpb1978.15.617

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Paramylon, a beta-(1 --> 3)-D-glucan, isolated from Euglena gracilis, was tested for its adjuvant activity on the antibody response to sheep red blood cell (SRBC) in mice. Paramylon markedly enhanced anti-SRBC plaque-forming cell production at a dose of 10 mg/kg. It was also found that in vitro addition of lipopolysaccharide in culture to macrophages from paramylon-treated mice produced a large amount of interleukin 1 (IL-1) and there was a significant level of interleukin 6 (IL-6) induced transiently in the blood of these mice. As IL-1 and IL-6 play crucial roles in the immune response to T cell-dependent antigens like SRBC, the immunopotentiating effect of paramylon might be expressed through the action of these cytokines.

引用

页码：617 / 621

页数：5

共 30 条

[1] TRIPLE HELICAL STRUCTURE OF LENTINAN, A LINEAR BETA-(1-]3)-D-GLUCAN [J].