VOLTAGE-GATED CA2+ CHANNEL BLOCKERS, OMEGA-AGAIVA AND NI2+, SUPPRESS THE INDUCTION OF THETA-BURST INDUCED LONG-TERM POTENTIATION IN GUINEA-PIG HIPPOCAMPAL CA1 NEURONS

被引：44

作者：

ITO, K

MIURA, M

FURUSE, H

CHEN, ZX

KATO, H

YASUTOMI, D

INOUE, T

MIKOSHIBA, K

KIMURA, T

SAKAKIBARA, S

MIYAKAWA, H

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT MOLEC NEUROBIOL,MINATO KU,TOKYO 108,JAPAN

[2] PEPTIDE INST INC,MINO,OSAKA 562,JAPAN

[3] TOKYO COLL PHARM,SCH LIFE SCI,CELLULAR NEUROBIOL LAB,HACHIOJI,TOKYO 19203,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 1-2期

关键词：

HIPPOCAMPUS; LONG-TERM POTENTIATION; OMEGA-AGAIVA; NICKEL; 2-AMINO-5-PHOSPHONOVALERATE; CA CHANNELS;

D O I：

10.1016/0304-3940(94)11127-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+](i)) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltage-gated Ca2+ channels (VGCC) in the induction of APS-sensitive LTP induced by theta-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+ (25 mu M, T-channel blocker) or omega-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the theta-burst induced LTP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

引用

页码：112 / 115

页数：4

共 23 条

[1] CHARACTERIZATION OF CA2+ SIGNALS INDUCED IN HIPPOCAMPAL CA1 NEURONS BY THE SYNAPTIC ACTIVATION OF NMDA RECEPTORS [J].