THE SIALYL LEWIS(X) GROUP AND ITS ANALOGS AS LIGANDS FOR SELECTINS - CHEMOENZYMATIC SYNTHESES AND BIOLOGICAL FUNCTIONS

被引：97

作者：

GIANNIS, A

机构：

[1] Institut Für Organische Chemie Und Biochemie, Universität Bonn, D-53121

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 02期

关键词：

D O I：

10.1002/anie.199401781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inhibitors of leukocyte adhesion have potential as antiphlogistics, antithrombotics, and immunosuppressants. The interaction of selectins and their membrane‐bound carbohydrate ligands is decisive for the initial phase of adhesion, and the sialyl Lewisx group 1 is a common ligand for all three selectins. Thus the ingenious chemoenzymatic synthesis of 1 and its analogues reported recently by Paulson, Wong, et al. has received much attention. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：178 / 180

页数：3

共 33 条

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