SYNTHESIS OF 6-AZA-PYRIMIDINE AND 6-METHYL-PYRIMIDINE RIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR INCORPORATION IN HAMMERHEAD RIBOZYMES

被引：13

作者：

BEIGELMAN, L ^{[1
]}

KARPEISKY, A ^{[1
]}

USMAN, N ^{[1
]}

机构：

[1] RIBOZYME PHARMACEUT INC,DEPT CHEM & BIOCHEM,BOULDER,CO 80301

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012497

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of phosphoramidites of 6-modified pyrimidine ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.

引用

页码：895 / 899

页数：5

共 6 条

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[3] SYNTHESIS OF NUCLEOSIDES .10. GENERAL SYNTHESIS OF N-GLYCOSIDES .2. SYNTHESIS OF 6-METHYLURIDINES
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[4] THEORETICAL DRUG DESIGN - 6-AZAURIDINE-5'-PHOSPHATE - ITS X-RAY CRYSTAL-STRUCTURE, POTENTIAL-ENERGY MAPS, AND MECHANISM OF INHIBITION OF OROTIDINE-5'-PHOSPHATE DECARBOXYLASE
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[J]. BIOPOLYMERS, 1979, 18 (08) : 2015 - 2036
[5] SCHWEIZER MP, 1973, J AM CHEM SOC, V95, P3370
[6] SYNTHESIS OF 4-(1,2,4-TRIAZOL-1-YL)PYRIMIDIN-2(1H)-ONE RIBONUCLEOTIDE AND ITS APPLICATION IN SYNTHESIS OF OLIGORIBONUCLEOTIDES
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