2ND GENERATION ANALOGS OF ETOPOSIDE AND MITOMYCIN-C

被引：26

作者：

DOYLE, TW

VYAS, DM

机构：

[1] Antitumor Chemistry and Microbiology, Pharmaceutical Research and Development, Bristol-Myers Squibb Company, Wallingford

来源：

CANCER TREATMENT REVIEWS | 1990年 / 17卷 / 2-3期

关键词：

D O I：

10.1016/0305-7372(90)90036-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Programs directed towards the selection of etoposide and mitomycin C analogs which exhibit superior activity, reduced toxicity and improved pharmaceutics have met with partial success. Etopofos (BMY 40481) has been chosen for development as a prodrug of etoposide possessing superior pharmaceutical properties. BMY 25067, an analog of mitomycin C, is also under development based on its improved activity profile, acceptable toxicology profile and possibly different mechanism of action. © 1990.

引用

页码：127 / 131

页数：5

共 20 条

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