OXIDATIVE DAMAGE TO LIPIDS WITHIN THE INFLAMED HUMAN JOINT PROVIDES EVIDENCE OF RADICAL-MEDIATED HYPOXIC-REPERFUSION INJURY

被引：37

作者：

MERRY, P ^{[1
]}

GROOTVELD, M ^{[1
]}

LUNEC, J ^{[1
]}

BLAKE, DR ^{[1
]}

机构：

[1] UNIV LONDON LONDON HOSP, COLL MED,LONDON INFLAMMAT GRP,ARC RES BLDG, 25-29 ASHFIELD ST, LONDON E1 2AD, ENGLAND

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 53卷 / 01期

关键词：

HYPOXIC-REPERFUSION INJURY; SYNOVITIS; FREE RADICALS; LIPID PEROXIDATION; ANTIOXIDANTS;

D O I：

10.1093/ajcn/53.1.362S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Previous work has established the existence of a pathophysiological environment within the inflamed human joint, capable of sustaining a hypoxic-reperfusion event. Using four different assay systems (two standard and two novel) applied to synovial fluid for the assessment of lipid peroxidation, a series of studies demonstrate that exercise of the inflamed human knee promotes radical-mediated lipid peroxidation within the joint. The implication for novel antioxidant therapeutic approaches to inflammatory joint disease is discussed.

引用

页码：S362 / S369

页数：8

共 46 条

[1]

ALLEN RE, 1989, LANCET, V2, P282

[2] EFFECT OF NUTRITIONAL IRON-DEFICIENCY ON ACUTE AND CHRONIC INFLAMMATION [J].