BIOSYNTHESIS OF LABELED FUMONISINS IN LIQUID CULTURES OF FUSARIUM-MONILIFORME

被引:49
作者
PLATTNER, RD
SHACKELFORD, DD
机构
[1] Bioactive Constituents Research Unit, National Center for Agricultural Utilization Research, USDA/ARS, Peoria, 61604, IL
关键词
FUMONISINS; FUSARIUM-MONILIFORME;
D O I
10.1007/BF00497274
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Fumonisins were readily produced in cultures of Fusarium moniliforme using a defined liquid medium. Addition of 200 mg of d3-methyl L-methionine to 100-ml cultures of F. moniliforme gave increased overall yields and high levels of deuterium (H-2) incorporation into fumonisin B1. Approximately 90% of the resulting fumonisin B1 contained 6 deuterium atoms, while 9% of the product contained 3 deuterium atoms. Deuterium was shown to be incorporated exclusively in the methyl groups of the fumonisin backbone. The addition of as little as 5 mg of labeled methionine stimulated fumonisin production, but only about 5% of the fumonisin produced contained 3 deuterium atoms.
引用
收藏
页码:17 / 22
页数:6
相关论文
共 16 条
[1]   STRUCTURE ELUCIDATION OF THE FUMONISINS, MYCOTOXINS FROM FUSARIUM-MONILIFORME [J].
BEZUIDENHOUT, SC ;
GELDERBLOM, WCA ;
GORSTALLMAN, CP ;
HORAK, RM ;
MARASAS, WFO ;
SPITELLER, G ;
VLEGGAAR, R .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (11) :743-745
[2]  
Booth C., 1971, GENUS FUSARIUM
[3]   FUMONISINS - NOVEL MYCOTOXINS WITH CANCER-PROMOTING ACTIVITY PRODUCED BY FUSARIUM-MONILIFORME [J].
GELDERBLOM, WCA ;
JASKIEWICZ, K ;
MARASAS, WFO ;
THIEL, PG ;
HORAK, RM ;
VLEGGAAR, R ;
KRIEK, NPJ .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1988, 54 (07) :1806-1811
[4]   PRODUCTION AND NATURE OF A HOST-SPECIFIC TOXIN FROM ALTERNARIA-ALTERNATA F-SP LYCOPERSICI [J].
GILCHRIST, DG ;
GROGAN, RG .
PHYTOPATHOLOGY, 1976, 66 (02) :165-171
[5]  
HALIBURTON JC, 1979, VET HUM TOXICOL, V21, P348
[6]  
Harrison L R, 1990, J Vet Diagn Invest, V2, P217
[7]  
KRIEK NPJ, 1981, ONDERSTEPOORT J VET, V48, P129
[8]  
MARASAS WFO, 1988, ONDERSTEPOORT J VET, V55, P197
[9]  
MARASAS WFO, 1984, TOXIGENIC FUSARIUM S, P216
[10]   A METHOD OF DETECTION OF FUMONISINS IN CORN SAMPLES ASSOCIATED WITH FIELD CASES OF EQUINE LEUKOENCEPHALOMALACIA [J].
PLATTNER, RD ;
NORRED, WP ;
BACON, CW ;
VOSS, KA ;
PETERSON, R ;
SHACKELFORD, DD ;
WEISLEDER, D .
MYCOLOGIA, 1990, 82 (06) :698-702