CHRONIC NICOTINE INTAKE DECELERATES AGING OF NIGROSTRIATAL DOPAMINERGIC-NEURONS

被引：30

作者：

PRASAD, C ^{[1
]}

IKEGAMI, H ^{[1
]}

SHIMIZU, I ^{[1
]}

ONAIVI, ES ^{[1
]}

机构：

[1] PENNINGTON BIOMED RES CTR, NEUROSCI RES CTR, BATON ROUGE, LA USA

来源：

LIFE SCIENCES | 1994年 / 54卷 / 16期

关键词：

NICOTINE; NIGROSTRIATAL DOPAMINERGIC NEURONS; PARKINSONS DISEASE; AGING;

D O I：

10.1016/0024-3205(94)00839-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have evaluated the effect of chronic nicotine intake on the age-associated loss of nigrostriatal dopaminergic neurons. The striatal density of dopamine (D1 and D-2) receptors and DA-uptake sites decreased with age. Concomitant with these changes was a pronounced loss of many behavioral functions associated, at least in part, with dopaminergic neurotransmission. Chronic oral intake of nicotine resulted in partial restoration of the loss of receptors as well as behavioral performances. The results suggest that low doses of nicotine could have beneficial effects during aging.

引用

页码：1169 / 1184

页数：16

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