A NEW CANDIDATE FOR A PROPERLY SUBSTITUTED CD RING COMPONENT OF VITAMIN-D-3 VIA INTRAMOLECULAR ASYMMETRIC OLEFINATION OF A 1,3-CYCLOPENTANEDIONE DERIVATIVE

被引：45

作者：

MANDAI, T

KAIHARA, Y

TSUJI, J

机构：

[1] Department of Applied Chemistry, Okayama University of Science, Okayama 700, Ridai-cho

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 20期

关键词：

D O I：

10.1021/jo00099a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly diastereoselective synthesis of hydrindenone derivative 5 (98% de) was achieved via diastereotopic differentiation of 1,3-cyclopentanedione derivative 4 by intramolecular Horner-Emmons olefination. In addition, the compound 5 was converted to ketone 2, a new building block far 1 alpha,25-dihydroxyvitamin D-3 (1).

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页码：5847 / 5849

页数：3

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