RANCINAMYCINS, METABOLITES PRODUCED BY STREPTOMYCES-LINCOLNENSIS IN SULFUR-DEPLETED MEDIA

被引：9

作者：

ARGOUDELIS, AD ^{[1
]}

PYKE, TR ^{[1
]}

SPRAGUE, RW ^{[1
]}

机构：

[1] UPJOHN CO, KALAMAZOO, MI 49001 USA

来源：

JOURNAL OF ANTIBIOTICS | 1976年 / 29卷 / 08期

关键词：

D O I：

10.7164/antibiotics.29.777

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rancinamycins I, II, III and IV are secondary metabolites produced by S. lincolnensis in a S-depleted culture medium. Rancinamycins I and II, the main components of the mixture, show broad spectrum antibiotic activity in vitro. S.c. injected or orally administered antibiotic afforded no protection for experimentally infected mice against lethal challenges of Staphylococcus aureus. Radioactive tracer studies failed to demonstrate that the rancinamycins were precursors in the biosynthesis of lincomycin.

引用

页码：777 / 786

页数：10

共 9 条

[1]

[Anonymous], AGENTS CHEMOTHER

[2]

ARGOUDEL.AD, 1970, J ANTIBIOT, V23, P1

[3] STUDIES ON BIOSYNTHESIS OF LINCOMYCIN .4. ORIGIN OF METHYL GROUPS [J].