STUDIES ON THE TOTAL SYNTHESIS OF STREPTOGRAMIN ANTI-BIOTICS - GRISEOVIRIDIN AND MADUMYCIN (A-2315A)

A convergent synthesis of the macrocyclic anti-biotics Madumycin II (A-2315A) 1 and Griseovi ridi n 2 is in progress. Al 1 of the stereochemical centers and functional groups have been incorporated with the former obtained as pure enantiomers. The routes, pitfalls, and strategy leading to the main synthetic fragments are disclosed. All that remains to complete the synthesis is the joining together of the two major units (5, 6, and 7 ). © 2013, Walter de Gruyter. All rights reserved.