CORRELATION BETWEEN PREDICTED BINDER SPREADING COEFFICIENTS AND MEASURED GRANULE AND TABLET PROPERTIES IN THE GRANULATION OF PARACETAMOL

The interfacial works of cohesion, adhesion, interaction parameters and spreading coefficients have been calculated for paracetamol granulated with hydroxypropyl methylcellulose, acacia, polyvinyl pyrrolidone and starch using literature values of surface free energies. In general, the predictions made regarding film formation, granule morphology and failure processes are consistent with literature data. Correlations have been found between the spreading coefficient of the binder over the substrate and actual experimental measurements of granule friability, tablet strength and tablet capping. The shape and complexity of the relationships can be further explained on the basis of the relative changes in binder cohesion. © 1990.