THE EMBRYONIC GAMMA-SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IS EXPRESSED IN ADULT EXTRAOCULAR-MUSCLE

被引：83

作者：

HORTON, RM

MANFREDI, AA

CONTITRONCONI, BM

机构：

[1] UNIV MINNESOTA,DEPT BIOCHEM,CBS,174 GORTNER LABS 1479 GORTNER AVE,ST PAUL,MN 55108

[2] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

NEUROLOGY | 1993年 / 43卷 / 05期

关键词：

D O I：

10.1212/WNL.43.5.983

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have PCR-amplified cDNA sequence of the 'embryonic'' gamma subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the gamma subunit in EOM mRNA, but not in control skeletal muscle. The presence of gamma subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the gamma subunit is generally present.

引用

页码：983 / 986

页数：4

共 20 条

[1] ILLEGITIMATE TRANSCRIPTION - TRANSCRIPTION OF ANY GENE IN ANY CELL TYPE [J].