THE INCIDENCE OF NARCOTIC-INDUCED EMESIS

被引:65
作者
CAMPORA, E
MERLINI, L
PACE, M
BRUZZONE, M
LUZZANI, M
GOTTLIEB, A
ROSSO, R
机构
[1] Department of Medical Oncology, Instituto Nazionale per la Ricerca sul Cancro, Genova
[2] Department of Pain, Service Instituto Nazionale per la Ricerca sul Cancro, Genova
关键词
NAUSEA AND VOMITING; NARCOTICS;
D O I
10.1016/0885-3924(91)90041-2
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Epidemiologic studies of the incidence of emesis induced by narcotic analgesics are lacking. The histories of 260 cancer patients receiving oral narcotic analgesics prescribed at the Pain Clinic of our Institute from December 1988 to December 1989 were reviewed. Of the 260 patients, 120 were women, median age 61 (range 30-90) yr and 140 were men, median age 62 (range 30-82) yr. Nausea and vomiting associated with assumption of the various narcotics were buprenorphine 8.3% and 22.7%, morphine 18.3% and 28%, codeine 16.2% and 29.7%, and oxycodone 10% and 40%, respectively. Since the use of narcotic analgesics can effectively relieve pain and improve quality of life in cancer patients, it is important to be aware of the incidence of narcotic-induced emesis in order to use appropriate prophylactic antiemetic therapy.
引用
收藏
页码:428 / 430
页数:3
相关论文
共 9 条
[1]  
Bonica, Treatment of cancer pain: current status and future needs, Advances in pain research and therapy, 9, pp. 589-616, (1985)
[2]  
Levin, Cleeland, Dar, Public attitudes toward cancer pain, Cancer, 56, pp. 2337-2339, (1985)
[3]  
World Health Organization, Cancer pain relief, (1986)
[4]  
Kris, Gralla, Clark, Et al., Antiemetic control and prevention of side effects of anticancer therapy with lorazepam or diphenhydramine when used in combination with metoclopramide plus dexamethazone: a double blind randomized trial, Cancer, 60, pp. 2816-2822, (1987)
[5]  
Marty, Pauillart, Scholl, Et al., Comparison of 5-hydroxytryptamine (serotonin) antagonist Ondansetron (GR 38032F) with high-dose metoclopramide in the control of cisplatin-induced emesis, New England Journal of Medicine, 322, pp. 815-821, (1990)
[6]  
Manara, Bianchetti, The central and peripheral influence of opioids on gastrointestinal propulsion, Annual Review of Pharmacology and Toxicology, 75, pp. 249-273, (1985)
[7]  
Bruera, Brenneis, Michaud, Et al., Continuous subcutaneous infusion of metoclopramide for the treatment of narcotic bowel syndrome, Cancer Treat Rep, 71, pp. 1121-1122, (1987)
[8]  
Billings, Nausea and vomiting, Outpatient management of advanced cancer, pp. 46-56, (1985)
[9]  
Lindley, Dalton, Fields, Narcotic analgesics. Clinical pharmacology and therapeutics, Cancer Nurs, 13, pp. 28-38, (1990)