INCREASED LEFT-VENTRICULAR MASS IN NORMOTENSIVE DIABETIC-PATIENTS WITH AUTONOMIC NEUROPATHY

被引：47

作者：

GAMBARDELLA, S

FRONTONI, S

SPALLONE, V

MAIELLO, MR

CIVETTA, E

LANZA, G

SANDRIC, S

MENZINGER, G

机构：

[1] Cattedra di Malattie del Ricambio, Universita di Roma Tor Vergata

[2] Istituto di Cardiolo- gia, Universita Cattolica del Sacro Cuore, Roma

[3] Malattie del Ricambio, CIC, Rome, 00168, Via della Pineta Sacchetti

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 02期

关键词：

DIABETES-MELLITUS; AUTONOMIC NEUROPATHY; NOCTURNAL BLOOD PRESSURE; LEFT VENTRICULAR MASS;

D O I：

10.1093/ajh/6.2.97

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The possible relationship between diabetic autonomic neuropathy, circadian blood pressure changes, and echocardiographic parameters was investigated in 27 normotensive diabetic patients (10 with and 17 without autonomic neuropathy) who underwent 24 h noninvasive ambulatory blood pressure monitoring and M-mode echocardiographic recording. The two groups were comparable for age, sex, duration of diabetes, body mass index, and metabolic control. There were no significant differences in 24 h average and diurnal values of systolic, diastolic, or mean blood pressure. The percent changes from day to night of systolic, diastolic, and mean blood pressures were significantly lower in diabetics with neuropathy than in those without (P < .04 or less). Increased left ventricular mass index (LVMI) (135.4 +/- 10.2 v 102.9 +/- 6.3; P < .005), septal wall thickness, and posterior wall width were observed in neuropathic patients. Fractional shortening, peak velocity of early left ventricular filling (E), peak velocity of late ventricular filling (A), and their ratio (E/A) were similar in the two groups. The increased LVMI we observed may represent a possible link between diabetic autonomic neuropathy, nocturnal blood pressure levels, and higher cardiovascular mortality rate.

引用

页码：97 / 102

页数：6

共 33 条

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