DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS

被引：39

作者：

MCCLEAN, S ^{[1
]}

OKANE, E ^{[1
]}

RAMACHANDRAN, VN ^{[1
]}

SMYTH, WF ^{[1
]}

机构：

[1] UNIV ULSTER,DEPT APPL PHYS SCI,COLERAINE BT52 1SA,LONDONDERRY,NORTH IRELAND

来源：

ANALYTICA CHIMICA ACTA | 1994年 / 292卷 / 1-2期

关键词：

DIFFERENTIAL PULSE POLAROGRAPHY; ATPASE INHIBITORS; THIOLS; OMEPRAZOLE;

D O I：

10.1016/0003-2670(94)00043-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in 10(-2) mol dm(-3) HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of 2-mercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.

引用

页码：81 / 89

页数：9

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