EMERGENCE OF ACUTE INTERSTITIAL PNEUMONIA FOLLOWING HIGH-DOSE INTERFERON PARTIAL-DERIVATIVE TREATMENT IN A CASE OF CHRONIC MYELOGENOUS LEUKEMIA

被引:7
作者
MURATA, M
NAGAI, M
BANDO, S
DOBASHI, H
TAKAHARA, J
机构
[1] First Department of Internal Medicine, Kagawa Medical School, Kagawa
关键词
CHEMOTHERAPY; ADVERSE EVENTS;
D O I
10.2169/internalmedicine.32.716
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Here we report a 58-year-old man with chronic myelogenous leukemia in the chronic phase, who developed acute respiratory failure following administration of high dose natural interferon partial derivative (6,300x10(4) units/week). Radiological and histological findings were consistent with acute interstitial pneumonia (AIP). Although the pathogenesis remains unclear, it is important to watch for the possible development of AIP when employing interferon partial derivative therapy, especially at high doses.
引用
收藏
页码:716 / 718
页数:3
相关论文
共 6 条
[1]  
Talpatz M., McCredie K.B., Mavligit G.M., Et al., Leukocyte interferoninduced myeloid cytoreduction in chronic myelogenous leukemia, Blood, 62, (1983)
[2]  
Rinald J.E., Brovetz H., Deterioration of oxygenation and abnormal lung microvascular permeability during resolution of leukopenia in patients with diffuse lung injury, Am Rev Respir Dis, 131, (1985)
[3]  
Cochrane C.G., Spragg R., Revak S.D., Pathogenesis of the adult respiratory distress syndrome: evidence of oxidant in bronchovascular lavage fluid, J Clin Invest, 71, (1983)
[4]  
Takeyama H., Yasui I., Kasai M., Yamada H., Watanabe E., Successful treatment of adult T-cell leukemia with Sho-Saiko-To and INF-σ-2b, Biotherapy, 5, (1991)
[5]  
Wadler S., Wiernik P.H., Clinical update on the role of Fluorouracil and recombinant interferon 3-2A in the treatment of colorectal carcinoma, Semin in Oncol, 17, (1990)
[6]  
Reynolds H.Y., Interstitial lung diseases, Harrison's Principles of Internal Medicine, (1991)