REGIOSELECTIVE ESTERIFICATION OF POLYHYDROXYLATED STEROIDS BY CANDIDA-ANTARCTICA LIPASE-B

被引：44

作者：

BERTINOTTI, A

CARREA, G

OTTOLINA, G

RIVA, S

机构：

[1] Istituto di Chimica degli Ormoni, C.N.R., 920131 Milano, Via Mario Bianco

来源：

TETRAHEDRON | 1994年 / 50卷 / 46期

关键词：

D O I：

10.1016/S0040-4020(01)89326-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselectivity of Candida antarctica lipase B towards the acetylation of polyhydroxylated steroids has been systematically investigated. The enzyme showed a marked preference for the alcoholic moieties on the A ring and on the steroid side chain, making it possible the selective acylation at the positions 3 or 21 of polyhydroxy steroids. Acylation with the synthetically useful esters chloroacetate and levulinate was also accomplished, whereas esterification with benzoate and pivaloate was unsuccessful.

引用

页码：13165 / 13172

页数：8

共 20 条

[1] INTRAMOLECULAR CATALYSIS .8. EFFECTS ON ACETYLATION OF 7 ALPHA-HYDROXYL GROUP OF STEROIDS - H-1 NUCLEAR MAGNETIC-RESONANCE RATE METHOD [J].