A GENE FROM THE HUMAN SEX-DETERMINING REGION ENCODES A PROTEIN WITH HOMOLOGY TO A CONSERVED DNA-BINDING MOTIF

被引：2558

作者：

SINCLAIR, AH ^{[1
]}

BERTA, P ^{[1
]}

PALMER, MS ^{[1
]}

HAWKINS, JR ^{[1
]}

GRIFFITHS, BL ^{[1
]}

SMITH, MJ ^{[1
]}

FOSTER, JW ^{[1
]}

FRISCHAUF, AM ^{[1
]}

LOVELLBADGE, R ^{[1
]}

GOODFELLOW, PN ^{[1
]}

机构：

[1] NATL INST MED RES,EUKARYOT MOLEC GENET LAB,LONDON NW7 1AA,ENGLAND

来源：

NATURE | 1990年 / 346卷 / 6281期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/346240a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF. © 1990 Nature Publishing Group.

引用

页码：240 / 244

页数：5

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