PENETRATION AND BIOCONVERSION OF DRUGS IN THE SKIN

被引：2

作者：

TOJO, K ^{[1
]}

LEE, ARC ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,WANG AMBULATORY CARE CTR,DEPT SURG,BOSTON,MA 02114

来源：

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN | 1991年 / 24卷 / 03期

关键词：

SKIN METABOLISM; PERCUTANEOUS ABSORPTION; PROVITAMIN; VITAMIN-C; VITAMIN-E; PRODRUG;

D O I：

10.1252/jcej.24.297

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The dynamic phenomena of skin diffusion/bioconversion of a provitamin have been described by assuming a bilayer skin consisting of the stratum corneum as a main diffusion barrier and the viable skin as a major site of bioconversion. The mathematical model adequately describes the time courses of the in vitro appearance profiles of the provitamin and its metabolites, vitamins C and E, in the hairless mouse skin. The present model can be used not only to investigate transdermal delivery of prodrugs but also to elucidate mechanisms of skin detoxification of xenobiotics entering the skin.

引用

页码：297 / 300

页数：4

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