PENETRATION AND BIOCONVERSION OF DRUGS IN THE SKIN

被引:2
作者
TOJO, K [1 ]
LEE, ARC [1 ]
机构
[1] MASSACHUSETTS GEN HOSP,WANG AMBULATORY CARE CTR,DEPT SURG,BOSTON,MA 02114
关键词
SKIN METABOLISM; PERCUTANEOUS ABSORPTION; PROVITAMIN; VITAMIN-C; VITAMIN-E; PRODRUG;
D O I
10.1252/jcej.24.297
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The dynamic phenomena of skin diffusion/bioconversion of a provitamin have been described by assuming a bilayer skin consisting of the stratum corneum as a main diffusion barrier and the viable skin as a major site of bioconversion. The mathematical model adequately describes the time courses of the in vitro appearance profiles of the provitamin and its metabolites, vitamins C and E, in the hairless mouse skin. The present model can be used not only to investigate transdermal delivery of prodrugs but also to elucidate mechanisms of skin detoxification of xenobiotics entering the skin.
引用
收藏
页码:297 / 300
页数:4
相关论文
共 15 条
[1]  
Barry, 1983, DERMATOLOGICAL FORMU
[2]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .7. DERMAL DELIVERY OF CROMOGLYCIC ACID (CROMOLYN) VIA ITS PRODRUGS [J].
BODOR, N ;
ZUPAN, J ;
SELK, S .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1980, 7 (01) :63-75
[3]   SCOPOLAMINE PERMEATION THROUGH HUMAN-SKIN INVITRO [J].
CHANDRASEKARAN, SK ;
MICHAELS, AS ;
CAMPBELL, PS ;
SHAW, JE .
AICHE JOURNAL, 1976, 22 (05) :828-832
[4]  
Chien Y. W., 1987, TRANSDERMAL CONTROLL
[5]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .9. KINETICS AND MECHANISM OF HYDROLYSIS OF METHYLSULFINYLMETHYL 2-ACETOXYBENZOATE AND RELATED ASPIRIN PRODRUGS [J].
LOFTSSON, T ;
BODOR, N .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (07) :750-755
[6]  
MIURA Y, 1964, J DERMATOL TOKYO, V74, P556
[7]  
Schaefer H, 1982, SKIN PERMEABILITY
[8]   HYDROXYMETHYL AND ACYLOXYMETHYL PRODRUGS OF THEOPHYLLINE - ENHANCED DELIVERY OF POLAR DRUGS THROUGH SKIN [J].
SLOAN, KB ;
BODOR, N .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1982, 12 (04) :299-313
[9]  
SUN Y, 1986, THESIS RUTGERS U
[10]   DRUG PERMEATION ACROSS THE SKIN - EFFECT OF PENETRANT HYDROPHILICITY [J].
TOJO, K ;
CHIANG, CC ;
CHIEN, YW .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (02) :123-126