MACROCYCLIC PEPTIDES .6. COMPLEX FORMATIONS AND CONFORMATIONS OF AN IONOPHOROUS CYCLIC OCTAPEPTIDE CONTAINING N,N'-ETHYLENE-BRIDGED (S)-LEUCYL-(S)-LEUCINE AND GLYCINE IN ACETONITRILE

被引：12

作者：

KOJIMA, Y ^{[1
]}

IKEDA, Y ^{[1
]}

MIYAKE, H ^{[1
]}

IWADOU, I ^{[1
]}

HIROTSU, K ^{[1
]}

SHIBATA, K ^{[1
]}

YAMASHITA, T ^{[1
]}

OHSUKA, A ^{[1
]}

SUGIHARA, A ^{[1
]}

机构：

[1] OSAKA MUNICIPAL TECH RES INST,OSAKA 530,JAPAN

来源：

POLYMER JOURNAL | 1991年 / 23卷 / 11期

关键词：

SOLUTION CONFORMATION; CATION-BINDING PROPERTIES; CD SPECTRA; CYCLIC OCTAPEPTIDE; GLYCINE; (S)-LEUCINE; H-1 AND C-13 NMR; PIPERAZIN-2-ONE; ENANTIOFACE-DIFFERENTIATING ABILITIES; 36-MEMBERED RING PEPTIDES; CATION-BINDING; DIPEPTIDES; SARCOSINE;

D O I：

10.1295/polymj.23.1359

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Complex formations and conformations of a synthetic cyclic octapeptide, cyclo[Gly-ELL-Gly]2 (1), with alkali and alkaline earth metal ions were investigated in acetonitrile by CD and NMR spectroscopies. The interactions between 1 and alkali metal complex ions (Li+, Na+, and K+) are considered to be very weak from small CD spectral changes. In the case of alkaline earth metal ions, titration curves obtained from CD data indicated the presence of only a PC (peptide-cation = 1:1) complex ion for Mg2+ and Ba2+, and of both P2C (peptide sandwich) and PC complex ions for Ca2+. The K1 values evaluated from the titration curves were in the order of Ca2+ > Ba2+ > Mg2+. Furthermore. H-1 and C-13 NMR measurements showed that 1 and the complex ions with Ca2+ and Ba2+ have each different C2-symmetric structure.

引用

页码：1359 / 1363

页数：5

共 12 条

[1] CYCLIC PEPTIDES .19. CATION BINDING OF A CYCLIC DODECAPEPTIDE CYCLO-(L-VAL-GLY-GLY-L-PRO)3 IN AN APROTIC MEDIUM [J].