TOTAL ETHANOL-CONSUMPTION AS A SEIZURE RISK FACTOR IN ALCOHOLICS

被引:31
作者
LECHTENBERG, R
WORNER, TM
机构
[1] SUNY HLTH SCI CTR,BROOKLYN,NY
[2] LONG ISL COLL HOSP,DEPT NEUROL,BROOKLYN,NY 11201
[3] LONG ISL COLL HOSP,ALCOHOLISM SERV,BROOKLYN,NY 11201
来源
ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 85卷 / 02期
关键词
ALCOHOLISM; SEIZURES; DETOXIFICATION;
D O I
10.1111/j.1600-0404.1992.tb04004.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Population studies suggest that seizures occur in chronic alcoholics as an effect of ethanol withdrawal or ethanol toxicity. Our own studies of individuals undergoing inpatient alcohol detoxification revealed a correlation between the number of detoxifications conducted and the probability that the individual will have a seizure disorder. To establish the basis for this association we studied drinking histories, drug use, and related characteristics of 500 individuals, 83 of whom were women, who enrolled in an inpatient detoxification program. Discriminant analyses revealed a direct correlation between average daily alcohol consumption and the prevalence of seizures in the alcoholic individuals studied. This correlation was significant, but it was not as strong as that between seizure prevalence and the number of times an individual underwent inpatient detoxification. This data supports the hypothesis that seizures occur in alcoholics because of a long-term kindling effect of recurrent detoxifications and a more short-term effect of ethanol exposure.
引用
收藏
页码:90 / 94
页数:5
相关论文
共 19 条
[1]   KINDLING AS A MODEL FOR ALCOHOL WITHDRAWAL SYNDROMES [J].
BALLENGER, JC ;
POST, RM .
BRITISH JOURNAL OF PSYCHIATRY, 1978, 133 (JUL) :1-14
[2]   ALCOHOL DETOXIFICATION AND WITHDRAWAL SEIZURES - CLINICAL SUPPORT FOR A KINDLING HYPOTHESIS [J].
BROWN, ME ;
ANTON, RF ;
MALCOLM, R ;
BALLENGER, JC .
BIOLOGICAL PSYCHIATRY, 1988, 23 (05) :507-514
[3]  
Cooper I S, 1973, Trans Am Neurol Assoc, V98, P192
[4]  
FELDMAN MH, 1970, ARCH NEUROL-CHICAGO, V22, P1
[5]  
GILMAN S, 1981, DISORDERS CEREBELLUM, P415
[6]   SHOULD ALCOHOL WITHDRAWAL SEIZURES BE TREATED WITH ANTI-EPILEPTIC DRUGS [J].
HILLBOM, ME ;
HJELMJAGER, M .
ACTA NEUROLOGICA SCANDINAVICA, 1984, 69 (01) :39-42
[7]  
HINTZE JL, 1989, NCSS VERSION 5 02
[8]  
KRINKE G, 1978, ACTA NEUROPATHOL, V43, P213
[9]   RELATIVE KINDLING EFFECT OF DETOXIFICATION AND NON-DETOXIFICATION ADMISSIONS IN ALCOHOLICS [J].
LECHTENBERG, R ;
WORNER, TM .
ALCOHOL AND ALCOHOLISM, 1991, 26 (02) :221-225
[10]   SEIZURE RISK WITH RECURRENT ALCOHOL DETOXIFICATION [J].
LECHTENBERG, R ;
WORNER, TM .
ARCHIVES OF NEUROLOGY, 1990, 47 (05) :535-538