DIFFERENTIATION-INDUCING ACTIVITY OF RETINOIC ACID ISOMERS AND THEIR OXIDIZED ANALOGS ON HUMAN PROMYELOCYTIC LEUKEMIA HL-60 CELLS

被引：26

作者：

MATSUSHIMA, Y ^{[1
]}

KAWACHI, E ^{[1
]}

TANAKA, H ^{[1
]}

KAGECHIKA, H ^{[1
]}

HASHIMOTO, Y ^{[1
]}

SHUDO, K ^{[1
]}

机构：

[1] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)92322-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinoidal activity of retinoic acid isomers [all-trans-retinoic acid (ATRA), 9-cis-retinoic acid (9CRA) and 13-cis-retinoic acid (13CRA)] and their oxidized derivatives [19-hydroxy and 19-oxo derivatives of ATRA (19-hydroxy-ATRA and 19-oxo-ATRA), 19-oxo derivative of 9CRA (19-oxo-9CRA), and 19-hydroxy derivative of 13CRA (19-hydroxy-13CRA)] was evaluated by means of a human promyelocytic leukemia HL-60 cell differentiation induction assay. All the compounds examined showed this activity with ED50 values of 2-30 nM, which are in accordance with their binding activity to nuclear retinoic acid receptors (RARs). © 1992.

引用

页码：1136 / 1142

页数：7

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