RELATION BETWEEN ANTIBODIES TO CHLAMYDIA-TRACHOMATIS AND SPONTANEOUS-ABORTION FOLLOWING INVITRO FERTILIZATION

被引：24

作者：

LICCIARDI, F ^{[1
]}

GRIFO, JA ^{[1
]}

ROSENWAKS, Z ^{[1
]}

WITKIN, SS ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,DEPT PHARMACOL,525 E 68TH ST,NEW YORK,NY 10021

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1992年 / 9卷 / 03期

关键词：

CHLAMYDIA-TRACHOMATIS; SPONTANEOUS ABORTION; INVITRO FERTILIZATION;

D O I：

10.1007/BF01203814

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Many couples undergo in vitro fertilization due to occlusion of the fallopian tubes. Chlamydia trachomatis infections are a major cause of this tubal damage. Since this organism has also been associated with poor pregnancy outcome, we investigated whether a past exposure to C. trachomatis was associated with spontaneous abortion following in vitro fertilization and embryo transfer. Methods: Sera from 145 women undergoing IVF were diluted 1:128 and tested for IgG antibodies to C. trachomatis by an immunoperoxidase assay, using infected cells fixed to slides. All subjects and their partners were negative for C. trachomatis by culture or by DNA hybridization. Results: Serological evidence of a past chlamydial infection was observed in 33.8% of the women. The incidence of antichlamydial IgG was greater (P < 0.001) in women whose infertility was due to known tubal disease (37 of 78; 47.4%) than in women whose infertility was due to other causes (12 of 67; 17.9%). Spontaneous abortions after embryo transfer occurred in 20% of the subjects. The incidence of antichlamydial IgG in aborting women (20 of 29; 69.0%) was greater (P < 0.001) than the incidence in either women with successful pregnancies (9 of 38; 23.7%) or women who did not become pregnant (20 of 78; 25.6%) after IVF. No relation was observed between antichlamydial antibody status and maternal age, the number of oocytes aspirated, the number of oocytes fertilized, and the number of embryos transferred. Conclusions: A previous infection with C. trachomatis may increase susceptibility to subsequent spontaneous abortion, even in the absence of a detectable current infection.

引用

页码：207 / 210

页数：4

共 13 条

[1]

Steer C., Campbell S., Davies M., Mason B., Collins W., Spontaneous abortion rates after natural and assisted conception, Br Med J, 299, pp. 1317-1318, (1988)

[2]

Quinn P., Petric M., Barkin M., The prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility, Am J Obstet Gynecol, 156, pp. 291-296, (1987)

[3]

Rowland G., Forsey T., Moss T., Steptoe P., Hewitt J., Darougar S., Failure of in vitro fertilization and embryo replacement following infection with Chlamydia trachomatis, J Vitro Fert Embryo Transfer, 2, pp. 151-155, (1985)

[4]

Torode H.N., Wheeler P.A., Saunders D.M., McPetric R.A., Medcalf S.C., Ackerman V.P., The role of Chlamydia antibodies in an in vitro fertilization program, Fertil Steril, 48, pp. 987-990, (1987)

[5]

Lunenfeld E., Shapiro B.S., Sarov B., Sarov I., Insler V., Decherney A., The association between Chlamydia-specific IgG and IgM antibodies and pregnancy outcome in an in vitro fertilization program, J Vitro Fert Embryo Transfer, 6, pp. 222-227, (1989)

[6]

Henry-Suchet J., Catalan F., Loffredo V., Serfaty D., Siboulet A., Perol Y., Sanson M.J., Debache C., Pigeau F., Coppin R., DeBrux J., Poynard T., Microbiology of specimens obtained by laparoscopy from controls and from patients with pelvic inflammatory disease with tubal obstruction: Chlamydia trachomatis and Ureaplasma urealyticum, Am J Obstet Gynecol, 138, pp. 1022-1025, (1980)

[7]

Gump D., Gibson M., Ashikaga T., Evidence of prior pelvic inflammatory disease and its relationship to Chlamydia trachomatis antibody and intrauterine contraceptive device use in infertile women, Am J Obstet Gynecol, 146, pp. 153-159, (1983)

[8]

Thejls H., Gnarpe J., Lundkvist O., Heimer G., Larsson G., Victor A., Diagnosis and prevalence of persistent Chlamydia infection in infertile women: tissue culture, direct antigen detection and serology, Fertil Steril, 55, pp. 304-310, (1991)

[9]

Morrison R., Lyng K., Caldwell H., Chlamydial disease pathogenesis. Ocular hypersensitivity elicited by a genus-specific 57 kD protein, J Exp Med, 169, pp. 663-675, (1989)

[10]

Grifo J.A., Jeremias J., Ledger W.J., Witkin S.S., Interferon gamma in the pathogenesis of pelvic inflammatory disease, Am J Obstet Gynecol, 160, pp. 26-31, (1989)

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