MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL CALCIUM-CHANNEL FROM RABBIT BRAIN

被引：116

作者：

NIIDOME, T

KIM, MS

FRIEDRICH, T

MORI, Y

机构：

[1] KYOTO UNIV, FAC MED, DEPT MED CHEM, YOSHIDA, SAKYO KU, KYOTO 60601, JAPAN

[2] KYOTO UNIV, FAC MED, DEPT MOLEC GENET, SAKYO KU, KYOTO 60601, JAPAN

来源：

FEBS LETTERS | 1992年 / 308卷 / 01期

关键词：

CALCIUM CHANNEL; CDNA CLONING; NUCLEOTIDE SEQUENCE; RNA BLOT HYBRIDIZATION; RABBIT BRAIN;

D O I：

10.1016/0014-5793(92)81038-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complete amino acid sequence of a novel calcium channel (designated BII) from rabbit brain has been deduced by cloning and sequencing the cDNA. The BII calcium channel is structurally more closely related to the BI calcium channel than to the cardiac and skeletal muscle L-type calcium channels. Blot hybridization analysis of RNA from different tissues and from different regions of the brain shows that the BII calcium channel is distributed predominantly in the brain, being abundant in the cerebral cortex, hippocampus and corpus striatum.

引用

收藏

页码：7 / 13

页数：7

相关论文

共 31 条

[1] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A HIGH-VOLTAGE ACTIVATED CALCIUM-CHANNEL FROM RABBIT LUNG [J].

BIEL, M ;

RUTH, P ;

BOSSE, E ;

HULLIN, R ;

STUHMER, W ;

FLOCKERZI, V ;

HOFMANN, F .

FEBS LETTERS, 1990, 269 (02) :409-412

[2] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[3]

GUY HR, 1990, TRENDS NEUROSCI, V13, P201

[4] CALCIUM-CHANNEL CHARACTERISTICS CONFERRED ON THE SODIUM-CHANNEL BY SINGLE MUTATIONS [J].

HEINEMANN, SH ;

TERLAU, H ;

STUHMER, W ;

IMOTO, K ;

NUMA, S .

NATURE, 1992, 356 (6368) :441-443

[5]

HESS P, 1990, ANNU REV NEUROSCI, V13, P337, DOI 10.1146/annurev.neuro.13.1.337

[6] SYNTHESIS AND PROCESSING OF ASPARAGINE-LINKED OLIGOSACCHARIDES [J].

HUBBARD, SC ;

IVATT, RJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 1981, 50 :555-583

[7] MOLECULAR-CLONING OF MULTIPLE SUBTYPES OF A NOVEL RAT-BRAIN ISOFORM OF THE ALPHA-1 SUBUNIT OF THE VOLTAGE-DEPENDENT CALCIUM-CHANNEL [J].

HUI, A ;

ELLINOR, PT ;

KRIZANOVA, O ;

WANG, JJ ;

DIEBOLD, RJ ;

SCHWARTZ, A .

NEURON, 1991, 7 (01) :35-44

[8] NATIVE-TYPE DHP-SENSITIVE CALCIUM-CHANNEL CURRENTS ARE PRODUCED BY CLONED RAT AORTIC SMOOTH-MUSCLE AND CARDIAC ALPHA-1 SUBUNITS EXPRESSED IN XENOPUS-LAEVIS OOCYTES AND ARE REGULATED BY ALPHA-2-SUBUNIT AND BETA-SUBUNIT [J].

ITAGAKI, K ;

KOCH, WJ ;

BODI, I ;

KLOCKNER, U ;

SLISH, DF ;

SCHWARTZ, A .

FEBS LETTERS, 1992, 297 (03) :221-225

[9] AUTORADIOGRAPHIC LOCALIZATION OF CALCIUM CHANNELS WITH [I-125] OMEGA-CONOTOXIN IN RAT-BRAIN [J].

KERR, LM ;

FILLOUX, F ;

OLIVERA, BM ;

JACKSON, H ;

WAMSLEY, JK .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 146 (01) :181-183

[10]

KOCH WJ, 1990, J BIOL CHEM, V265, P17786

← 1 2 3 4 →