NOVEL NONOPIOID NON-ANTIINFLAMMATORY ANALGESICS - 3-(AMINOALKYL) AND 3-[(4-ARYL-1-PIPERAZINYL)ALKYL]OXAZOLO[4,5-B]PYRIDIN-2(3H)-ONES

被引：47

作者：

FLOUZAT, C

BRESSON, Y

MATTIO, A

BONNET, J

GUILLAUMET, G

机构：

[1] UNIV ORLEANS,CNRS,CHIM BIOORGAN & ANALYT LAB,BP 6759,F-45067 ORLEANS 2,FRANCE

[2] INST RECH SERVIER,F-92150 SURESNES,FRANCE

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 04期

关键词：

D O I：

10.1021/jm00056a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-(aminoalkyl)- and 3-[(4-aryl-1-piperazinyl)alkyl]oxazolo[4,5-b]pyridin-2(3H)-ones were prepared from their respective oxazolo[4,5-b]pyridin-2(3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two-carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity having neither an antiinflammatory effect nor opioid receptor affinity. The synthesis and structure-affinity relationships for this series are detailed.

引用

页码：497 / 503

页数：7

共 25 条

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