MECHANISMS OF SOLUBLE MEDIATORS

被引：7

作者：

AKIRA, S ^{[1
]}

KISHIMOTO, T ^{[1
]}

机构：

[1] OSAKA UNIV,OSAKA,JAPAN

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 03期

关键词：

D O I：

10.1016/0952-7915(92)90081-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A two chain model, composed of ligand-binding and signal transducing subunits, first indentified in the interleukin-6 receptor system, has been revealed in several other cytokine systems. Common signal transducers shared by several receptor systems may explain a functional redundancy characteristic of cytokines. The signaling pathway from the receptor to gene activation is now becoming clearer due to the successful molecular cloning of several transcription factors.

引用

页码：307 / 313

页数：7

共 43 条

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