SEROTONIN DIFFERENTIALLY MODULATES RESPONSES MEDIATED BY SPECIFIC EXCITATORY AMINO-ACID RECEPTORS IN THE RAT LOCUS-CERULEUS

被引:32
作者
CHARLETY, PJ
CHERGUI, K
AKAOKA, H
SAUNIER, CF
BUDA, M
ASTONJONES, G
CHOUVET, G
机构
[1] CTR HOSP LYON SUD, INSERM, U171, F-69310 PIERRE BENITE, FRANCE
[2] HAHNEMANN UNIV, SCH MED, DEPT MENTAL HLTH SCI, DIV BEHAV NEUROBIOL, PHILADELPHIA, PA 19102 USA
[3] CTR HOSP LYON SUD, CNRS, URA 1195, F-69310 PIERRE BENITE, FRANCE
关键词
KAINATE; QUISQUALATE; N-METHYL-D-ASPARTATE; MICROIONTOPHORESIS; IN-VIVO ELECTROPHYSIOLOGY;
D O I
10.1111/j.1460-9568.1993.tb00954.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Microiontophoretic application of selective agonists for the three major excitatory amino acid receptors, N-methyl-D-aspartate (NMDA), quisqualate and kainate, increased the discharge rate of noradrenergic locus coeruleus (LC) neurons in vivo. NMDA activation was selectively attenuated by iontophoretic application of 2-amino-5-phosphonopentanoate (AP5), an antagonist at NMDA receptors, whereas kainate- and quisqualate-evoked responses were attenuated by both NMDA and non-NMDA antagonists iontophoresis. NMDA- and quisqualate-evoked responses were significantly decreased by co-iontophoresis of serotonin (5-HT). When the NMDA receptor-mediated component of the response to kainate was blocked with AP5 iontophoresis, 5-HT increased the response of LC neurons to kainate. These results revealed that 5-HT differentially modulates the responsiveness of LC neurons to excitatory amino acids, depending on the receptor subtypes responsible for the neuronal activation.
引用
收藏
页码:1024 / 1028
页数:5
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