BIOLOGICALLY-CLEAVABLE PHOSPHATE PROTECTIVE GROUPS - 4-ACYLOXY-1,3,2-DIOXAPHOSPHORINANES AS NEUTRAL LATENT PRECURSORS OF DIANIONIC PHOSPHATES

被引：11

作者：

FARQUHAR, D

KHAN, S

WILKERSON, MC

ANDERSSON, BS

机构：

[1] Department of Clinical Investigation, The University of Texas M. D. Anderson Cancer Center, Houston

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(94)02344-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Phenoxy-2-oxo-4-pivaloyloxy-1,3,2-dioxophosphorinane (1) was prepared as a stable, neutral precursor of phenyl phosphate. In the presence of 20% human plasma, 1 was converted quantitatively to phenyl phosphate with a half-life of 15 min.

引用

页码：655 / 658

页数：4

共 5 条

[1] STEREOELECTRONIC EFFECTS IN THE REACTIONS OF EPIMERIC 2-ARYLOXY-2-OXY-1,3,2-DIOXAPHOSPHORINANES AND OXAZAPHOSPHORINANES [J].

GORENSTEIN, DG ;

ROWELL, R ;

FINDLAY, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (15) :5077-5081

[2]

KRISCH K, 1971, ENZYMES, V5, P59

[3]

Liebermann K. C, 1955, J BIOL CHEM, V316, P823

[4] DIPOLE-MOMENT, NUCLEAR MAGNETIC-RESONANCE, AND IR STUDIES OF PHOSPHORUS CONFIGURATIONS AND EQUILIBRIA IN "2-R-2-OXO-1,3,2-DIOXAPHOSPHORINANES [J].

MOSBO, JA ;

VERKADE, JG .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (09) :1549-1555

[5]

ROLL PM, 1956, J BIOL CHEM, V220, P439

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