A BARLEY CDNA CLONE WITH HOMOLOGY TO THE DNA-BINDING DOMAIN OF THE STEROID-HORMONE RECEPTORS

被引：13

作者：

SPEULMAN, E ^{[1
]}

SALAMINI, F ^{[1
]}

机构：

[1] MAX PLANCK INST ZUCHTUNGSFORSCH,D-50829 COLOGNE,GERMANY

来源：

PLANT SCIENCE | 1995年 / 106卷 / 01期

关键词：

HORDEUM VULGARE; STEROID HORMONE RECEPTORS; DNA-BINDING DOMAIN; ZINC-FINGER;

D O I：

10.1016/0168-9452(95)04072-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The steroid hormone receptors are members of a superfamily of nuclear receptors that regulate gene expression in response to a ligand in mammals and insects. A cDNA library from barley (Hordeum vulgare) was screened with highly degenerated oligonucleotides corresponding to 11 and 6 amino acids of the highly conserved DNA-binding domain of the steroid hormone receptors. A full length cDNA clone (ES43) was isolated. The sequence of ES43 shows homology to the DNA-binding domain of the estrogen receptor, including three amino acids (Glu(191), Gly(192) and Ala(195)) at conserved positions, which determine the binding specificity of the estrogen receptor to its hormone response element. Additional homologies concerning critical amino acid positions with all members of the nuclear receptor superfamily are also evident.

引用

页码：91 / 98

页数：8

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