PAPAVERINE-SENSITIVE VASOSPASM AND ARTERIAL CONTRACTILITY AND COMPLIANCE AFTER SUBARACHNOID HEMORRHAGE IN DOGS

被引:55
作者
MACDONALD, RL
ZHANG, J
SIMA, B
JOHNS, L
机构
[1] Section of Neurosurgery, University of Chicago Medical Center, Chicago, IL
关键词
DOG; PAPAVERINE; SMOOTH MUSCLE; SUBARACHNOID HEMORRHAGE; VASOSPASM;
D O I
10.1227/00006123-199511000-00016
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
THIS STUDY EXAMINED the relationship between papaverine-sensitive and -insensitive components of vasospasm, arterial contractility and compliance, and time after subarachnoid hemorrhage (SAH) in dogs. Eighteen dogs underwent angiography and then two intracisternal injections of blood. Angiography was repeated 4 (n = 5), 7 (n = 4), 10 (n = 4), or 14 (n = 5) days later. Papaverine, 100 to 200 mg, was infused into the basilar artery, and angiography was repeated. Four additional dogs had cerebral angiography only and served as controls. The basilar arteries were removed and studied pharmacologically. Significant vasospasm of the basilar artery was observed each time after SAH. Papaverine significantly reversed vasospasm at 4 and 7 days (88 +/- 6% and 63 +/- 11% of vasospasm reversed; analysis of variance, P < 0.05). The papaverine-insensitive component of vasospasm increased significantly with increasing time after SAH and with increasing severity of vasospasm. Arterial contractility and compliance decreased significantly with increasing time after SAH and were significantly related to the degree of papaverine-insensitive vasospasm but not to the severity of vasospasm. In conclusion, the majority of vasospasm early after SAH in dogs was caused by reversible vasoconstriction. The ability of papaverine to reverse vasospasm depended on the time after SAH and on the severity of vasospasm, a finding that may be important to the use of papaverine in humans. The pathological and biochemical basis for the association between papaverine-insensitive vasospasm and reduced arterial wall contractility and compliance remains to be determined.
引用
收藏
页码:962 / 967
页数:6
相关论文
共 22 条
[1]   FUNCTIONAL ARTERIAL CHANGES IN CHRONIC CEREBROVASOSPASM IN MONKEYS - AN INVITRO ASSESSMENT OF THE CONTRIBUTION TO ARTERIAL NARROWING [J].
BEVAN, JA ;
BEVAN, RD ;
FRAZEE, JG .
STROKE, 1987, 18 (02) :472-481
[2]   EARLY CHANGES IN RABBIT CEREBRAL-ARTERY REACTIVITY AFTER SUBARACHNOID HEMORRHAGE [J].
DEBDI, M ;
SEYLAZ, J ;
SERCOMBE, R .
STROKE, 1992, 23 (08) :1154-1162
[3]   CEREBRAL-ARTERY SPASM - HISTOLOGICAL STUDY AT NECROPSY OF BLOOD-VESSELS IN CASES OF SUBARACHNOID HEMORRHAGE [J].
HUGHES, JT ;
SCHIANCHI, PM .
JOURNAL OF NEUROSURGERY, 1978, 48 (04) :515-525
[4]   SUPERSELECTIVE INTRAARTERIAL INFUSION OF PAPAVERINE FOR THE TREATMENT OF CEREBRAL VASOSPASM AFTER SUBARACHNOID HEMORRHAGE [J].
KAKU, Y ;
YONEKAWA, Y ;
TSUKAHARA, T ;
KAZEKAWA, K .
JOURNAL OF NEUROSURGERY, 1992, 77 (06) :842-847
[5]   TREATMENT OF CEREBRAL VASOSPASM WITH INTRAARTERIAL PAPAVERINE [J].
KASSELL, NF ;
HELM, G ;
SIMMONS, N ;
PHILLIPS, CD ;
CAIL, WS .
JOURNAL OF NEUROSURGERY, 1992, 77 (06) :848-852
[6]   ALTERATIONS OF MECHANICAL-PROPERTIES IN CANINE BASILAR ARTERIES AFTER SUBARACHNOID HEMORRHAGE [J].
KIM, P ;
SUNDT, TM ;
VANHOUTTE, PM .
JOURNAL OF NEUROSURGERY, 1989, 71 (03) :430-436
[7]   ALTERATIONS IN ENDOTHELIUM-DEPENDENT RESPONSIVENESS OF THE CANINE BASILAR ARTERY AFTER SUBARACHNOID HEMORRHAGE [J].
KIM, P ;
SUNDT, TM ;
VANHOUTTE, PM .
JOURNAL OF NEUROSURGERY, 1988, 69 (02) :239-246
[8]   NIMODIPINE AND CHRONIC VASOSPASM IN MONKEYS .2. PHARMACOLOGICAL STUDIES OF VESSELS IN SPASM [J].
KRUEGER, C ;
WEIR, B ;
NOSKO, M ;
COOK, D ;
NORRIS, S .
NEUROSURGERY, 1985, 16 (02) :137-140
[9]   Papaverine Hydrochloride and Experimental Hemorrhagic Cerebral Arterial Spasm [J].
Kuwayama, Akio ;
Zervas, Nicholas T. ;
Shintani, Akira ;
Pickren, Kenneth S. .
STROKE, 1972, 3 (01) :27-33
[10]   CYTOSKELETAL AND EXTRACELLULAR-MATRIX PROTEINS IN CEREBRAL-ARTERIES FOLLOWING SUBARACHNOID HEMORRHAGE IN MONKEYS [J].
MACDONALD, RL ;
WEIR, BKA ;
YOUNG, JD ;
GRACE, MGA .
JOURNAL OF NEUROSURGERY, 1992, 76 (01) :81-90