INCLUSION COMPLEX-FORMATION OF ANTHRACYCLINE ANTIBIOTICS WITH CYCLODEXTRINS - A PROTON NUCLEAR-MAGNETIC-RESONANCE AND MOLECULAR MODELING STUDY

被引：29

作者：

BEKERS, O

KETTENESVANDENBOSCH, JJ

VANHELDEN, SP

SEIJKENS, D

BEIJNEN, JH

BULT, A

UNDERBERG, WJM

机构：

[1] NETHERLANDS CANC INST,1066 CX AMSTERDAM,NETHERLANDS

[2] STATE UNIV UTRECHT,FAC CHEM,3584 CH UTRECHT,NETHERLANDS

来源：

JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1991年 / 11卷 / 02期

关键词：

ANTHRACYCLINES; CYCLODEXTRINS; COMPLEX FORMATION; COMPLEX STRUCTURE; H-1-NMR; MOLECULAR MODELING;

D O I：

10.1007/BF01153301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inclusion complexation of the anthracyline antibiotics doxorubicin and daunorubicin with cyclodextrins has been studied by proton NMR and molecular modelling. The anthracyclines were found to complex with gamma-cyclodextrin, whereby the aglyconic part of the molecule is included in the cyclodextrin cavity. Job ratio plots based on NMR data indicate that the complex has a stoichiometry of 1:1. Complex constant values of 345 M-1 and 323 M-1 (at pH 3) were found for doxorubicin and daunorubicin, respectively.

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页码：185 / 193

页数：9

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