CHROMOSOMAL-ABERRATIONS, SISTER-CHROMATID EXCHANGES, CELL-CYCLE KINETICS AND SATELLITE ASSOCIATIONS IN HUMAN LYMPHOCYTE-CULTURES EXPOSED TO VANADIUM PENTOXIDE

被引：40

作者：

ROLDAN, RE

ALTAMIRANO, LMA

机构：

[1] Laboratorio de Citogenética y Mutagénesis, Campo II, Escuela Nacional de Estudios Profesionales-Zaragoza, Mexico

来源：

MUTATION RESEARCH | 1990年 / 245卷 / 02期

关键词：

Cell-cycle kinetics; Chromosomal aberration; Satellite associations; Sister-chromatid exchange; Vanadium pentoxide;

D O I：

10.1016/0165-7992(90)90001-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Treatment of human lymphocytes with vanadium pentoxide (V205) was not found to increase the frequency of structural chromosomal aberrations (CA) and sister-chromatid exchanges (SCE). However, V205 significantly increased polyploid cell frequency; also, the mitotic index (MI) was significantly decreased, and the average generation time (AGT) was significantly increased. Finally, the frequency of cells with satellite associations (SA), the frequency of SA per cell, and the frequency of chromosomes associated increased in treated cultures. © 1990.

引用

页码：61 / 65

页数：5

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