FLOW-INJECTION ANALYSIS AND BATCH PROCEDURES FOR THE ROUTINE DETERMINATION OF N-PENICILLAMINE

A simple method for the determination of N-penicillamine based on the formation of a yellow complex with Co(II) is proposed. The calibration graph is linear in the 2 × 10-5-3 × 10-4 M range. The method can be easily adapted for flow injection analysis, the peak height being proportional to the drug concentration over the 10-4-2 × 10-3 M range. The application of the peak-width method using a gradient tube allows an extension of the working range. Thus, N-penicillamine can be determined between 5 × 10-5 and 0.1 M. © 1990.