TEMPERATURE-DEPENDENCE OF HYPOXIA-INDUCED CALCIUM ACCUMULATION IN GERBIL HIPPOCAMPAL SLICES

被引：77

作者：

MITANI, A

KADOYA, F

KATAOKA, K

机构：

[1] Department of Physiology, School of Medicine, Ehime University, Ehime

来源：

BRAIN RESEARCH | 1991年 / 562卷 / 01期

关键词：

HYPOTHERMIA; HYPOXIA; MICROFLUOROMETRY; RHOD-2; CALCIUM; HIPPOCAMPUS; EXTRACELLULAR DC POTENTIAL;

D O I：

10.1016/0006-8993(91)91201-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microfluorometry was used to investigate temperature dependence of hypoxia-induced intracellular calcium accumulation in gerbil hippocampal slice. When slices were superfused with hypoxic medium at 37-degrees-C, 35-degrees-C, 33-degrees-C or 31-degrees-C, latencies of acute increase of calcium accumulation, which was accompanied by a large negative shift of extracellular DC potentials, were delayed in a dose-dependent manner: mean latencies in field CA1 were 130 s, 182 s, 232 s and 277 s after hypoxia, respectively. This retardation in calcium accumulation may be involved in the mechanisms by which hypothermia diminishes ischemic injury.

引用

页码：159 / 163

页数：5

共 16 条

[1] EFFECT OF MILD HYPOTHERMIA ON ISCHEMIA-INDUCED RELEASE OF NEUROTRANSMITTERS AND FREE FATTY-ACIDS IN RAT-BRAIN [J].