VARIATIONS IN ATP-SENSITIVE K+ CHANNEL ACTIVITY PROVIDE EVIDENCE FOR INHERENT METABOLIC OSCILLATIONS IN PANCREATIC BETA-CELLS

被引：50

作者：

DRYSELIUS, S

LUND, PE

GYLFE, E

HELLMAN, B

机构：

[1] Department of Medical Cell Biology, Uppsala University, Uppsala S-75123, Biomedicum

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2746

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell-attached configuration of the patch clamp technique was used for studying slow variations in the activity of the ATP-sensitive K+ channels in pancreatic beta-cells isolated from mouse and man. In 0 or 3 mM glucose, the fraction of time the channels were open exhibited oscillations with frequencies in the 0.25-0.40 /min range. This phenomenon is a strong argument for inherent fluctuations in the ATP production of the beta-cells. variations in metabolism may thus be a major determinant for the characteristic large amplitude oscillations of cytoplasmic Ca2+ with equivalent frequency. (C) 1994 Academic Press, Inc.

引用

页码：880 / 885

页数：6

共 25 条

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