EFFECT OF DEXTRAN ON GENTAMICIN-INDUCED OTOTOXICITY

被引：1

作者：

MANABE, Y

SAITO, T

TSUZUKI, H

IGARASHI, M

YAMAGISHI, T

SAITO, H

机构：

[1] Department of Otolaryngology, Fukui Medical School, Fukui

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1995年 / 57卷 / 03期

关键词：

GENTAMICIN; DEXTRAN; OTOTOXICITY; NEPHROTOXICITY;

D O I：

10.1159/000276722

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The effect of low-molecular-weight dextran (DX) on gentamicin (GM)induced ototoxicity was examined in guinea pigs. GM (100 mg/kg) was administered intramuscularly for 10, 12 and 14 days with or without DX. Cochlear damage was evaluated by compound action potential thresholds and surface preparation after fixation with osmium tetroxide. The percentage of missing outer hair cells was significantly increased by combined administrations of GM with DX. However, there was no significant difference in blood urea nitrogen levels in guinea pigs with or without DX. When aminoglycoside antibiotics and DX are administered together, attention should be paid not only to nephrotoxicity but also to ototoxicity.

引用

页码：111 / 114

页数：4

共 13 条

[1]

Appei G.B., Aminoglycoside nephrotoxicity, Am J Med, 88, pp. 16-20, (1990)

[2]

Maningas P.A., Mattox K.L., Pepe P.E., Jones R.L., Feliciano D.V., Burch J.M., Hypertonic saline-dextran solutions for the prehospital management of traumatic hypotension, Am J Surg, 157, pp. 528-533, (1989)

[3]

Stennert E., New concept in the treatment of Bell's palsy, Disorders of the Facial Nerve, pp. 313-317, (1982)

[4]

Davies D.M., A world survey of anticoagulation practice in clinical microvascular surgery, Br J Plast Surg, 35, pp. 96-99, (1982)

[5]

West B.A., Brummett R.E., Himes D.L., Interaction of kanamycin and ethacrynic acid, Arch Otolaryngol, 98, pp. 32-37, (1973)

[6]

Russell N.J., Fox K.E., Brummett R.E., Ototoxic effects of the interaction between kanamycin and ethacrynic acid, Acta Otolaryngol (Stockh), 88, pp. 369-381, (1979)

[7]

Nakazono M., Biochemical studies on nephrotoxicity of kanamycin, Jpn J Urol, 62, pp. 115-124, (1971)

[8]

Takeda H., Tanaka Y., Wada K., Morimoto T., Arakawa M., Nephrotoxicity of netilmicin with a combination of 10% low molecular weight dextran solution or cephalothin in rabbits, Chemotherapy (Tokyo), 30, pp. 607-612, (1982)

[9]

March W.H., Fingerhut B., Muller H., Automated and manual direct methods for the determination of blood urea, Clin Chem, 11, pp. 624-629, (1965)

[10]

Jolley M.E., Stroup S.D., Wang C.H.J., Panas H.N., Keegan C.L., Schmidt R.L., Schmenzer K.S., Fluorescence polarization immunoassay. I. Monitoring aminoglycoside antibiotics in serum and plasma, Clin Chem, 27, pp. 1190-1197, (1981)

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