VERY-LOW INTRALUMINAL COLONIC PH IN PATIENTS WITH ACTIVE ULCERATIVE-COLITIS

被引:176
作者
FALLINGBORG, J
CHRISTENSEN, LA
JACOBSEN, BA
RASMUSSEN, SN
机构
[1] Department of Medical Gastroenterology, Aalborg Hospital South, Aalborg
关键词
PH; INTRALUMINAL PH; ULCERATIVE COLITIS; LACTATE; ACTIVITY;
D O I
10.1007/BF01297074
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Intraluminal gastrointestinal pH was measured in seven patients with active ulcerative colitis (four male, three female). A radiotelemetry capsule was used, and its location was determined by fluoroscopy. Satisfactory measurements were obtained from six, in all of whom pH levels were normal in the stomach and small intestine. Three patients also had normal pH values in the colon. However, in the remaining three patients very low pH levels (lowest values 2.3, 2.9, and 3.4) were found in the proximal parts of the colon. Five of the seven patients, including the three with low pH in the colon, underwent colectomy. The mechanism behind the low intraluminal pH in some patients with ulcerative colitis is speculative. Increased fecal concentrations of lactate occur in active disease, but some of the pH values measured in our study were below the pK(a) value of lactate. The study demonstrates that very low intraluminal pH levels in the colon occur in some patients with active ulcerative colitis. This might be an indicator of severe activity of the disease.
引用
收藏
页码:1989 / 1993
页数:5
相关论文
共 11 条
[1]  
BINDER V, 1970, SCAND J GASTROENTERO, V5, P627
[2]   EFFECTS OF LACTULOSE AND OTHER LAXATIVES ON ILEAL AND COLONIC PH AS MEASURED BY A RADIOTELEMETRY DEVICE [J].
BOWN, RL ;
GIBSON, JA ;
SLADEN, GE ;
HICKS, B ;
DAWSON, AM .
GUT, 1974, 15 (12) :999-1004
[3]   RISK-FACTORS IN TOXIC MEGACOLON [J].
CAPRILLI, R ;
VERNIA, P ;
COLANERI, O ;
FRIERI, G .
DIGESTIVE DISEASES AND SCIENCES, 1980, 25 (11) :817-822
[4]  
COLSON RH, 1981, BIOTELEM PAT MON, V8, P213
[5]  
FALLINGBORG J, 1989, ALIMENT PHARM THERAP, V3, P605
[6]  
PYE G, 1987, GUT, V28, pA1366
[7]   COLONIC BICARBONATE OUTPUT AS A TEST OF DISEASE-ACTIVITY IN ULCERATIVE-COLITIS [J].
ROEDIGER, WEW ;
LAWSON, MJ ;
KWOK, V ;
GRANT, AK ;
PANNALL, PR .
JOURNAL OF CLINICAL PATHOLOGY, 1984, 37 (06) :704-707
[8]  
ROEDIGER WEW, 1982, GASTROENTEROLOGY, V83, P424
[9]  
ROEDIGER WEW, 1980, LANCET, V2, P712
[10]   FECAL LACTATE AND ULCERATIVE-COLITIS [J].
VERNIA, P ;
CAPRILLI, R ;
LATELLA, G ;
BARBETTI, F ;
MAGLIOCCA, FM ;
CITTADINI, M .
GASTROENTEROLOGY, 1988, 95 (06) :1564-1568