GROUP-CONTRIBUTION METHOD FOR PREDICTING PROBABILITY AND RATE OF AEROBIC BIODEGRADATION

被引:180
作者
BOETHLING, RS
HOWARD, PH
MEYLAN, W
STITELER, W
BEAUMAN, J
TIRADO, N
机构
[1] US EPA, OFF POLLUT PREVENT & TOX 7406, 401 M ST SW, WASHINGTON, DC 20460 USA
[2] SYRACUSE RES CORP, SYRACUSE, NY 13210 USA
关键词
D O I
10.1021/es00052a018
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Two independent training sets were used to develop four mathematical models for predicting aerobic biodegradability from chemical structure. All four of the models are based on multiple regressions against counts of 36 preselected chemical substructures plus molecular weight. Two of the models, based on linear and nonlinear regressions, calculate the probability of rapid biodegradation and can be used to classify chemicals as rapidly or not rapidly biodegradable. The training set for these models consisted of qualitative summary evaluations of all available experimental data on biodegradability for 295 chemicals. The other two models allow semi-quantitative prediction of primary and ultimate biodegradation rates using multiple linear regression. The training set for these models consisted of estimates of primary and ultimate biodegradation rates for 200 chemicals, gathered in a survey of 17 biodegradation experts. The two probability models correctly classified 90% of the chemicals in their training set, whereas the two survey models calculated biodegradation rates for the survey chemicals with R2 is-approximately-equal-to 0.7. These four models are intended for use in chemical screening and in setting priorities for further review.
引用
收藏
页码:459 / 465
页数:7
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