GENOMIC STRUCTURE OF THE MOUSE A-TYPE LAMIN GENE LOCUS ENCODING SOMATIC AND GERM CELL-SPECIFIC LAMINS

被引：45

作者：

NAKAJIMA, N ^{[1
]}

ABE, K ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT VIROL,TOKYO,JAPAN

来源：

FEBS LETTERS | 1995年 / 365卷 / 2-3期

关键词：

NUCLEAR ENVELOPE; LAMIN; NUCLEOTIDE SEQUENCE; GENE STRUCTURE; PROMOTER; DIFFERENTIAL PROCESSING;

D O I：

10.1016/0014-5793(95)00453-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse A-type Iamin genes were isolated, Structural analyses revealed that all the three known mouse A-type lamins (A, C and C2) were coded in. a single genomic locus in a 22 kilobase DNA segment, The three lamins were coded in 12, 10 and 10 exons for A, C and C2, respectively, and shared 8 exons among them, Primer extension analyses identified possible transcription start sites for both A/C and C2 genes suggesting that the locus is under the control of two separate promoters, that is a somatic cell-acting promoter (for A and C) and a testis-specific promoter (for C2) which resides in the first intron of the A/C gene, Sequence characteristics of the possible promoter regions are discussed, Divergence of the two somatic cell-type lamins (A and C) is formally accounted for by differential selection of poly(A) sites together with lamin A-specific splicing.

引用

页码：108 / 114

页数：7

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