ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA ASSOCIATED WITH TETANUS TOXOID VACCINATION

被引：39

作者：

AKOSA, AB

ALI, MH

KHOO, CTK

EVANS, DM

机构：

[1] WEXHAM PK HOSP,DEPT HISTOPATHOL,SLOUGH SL2 4HL,BERKS,ENGLAND

[2] WEXHAM PK HOSP,DEPT PLAST SURG,SLOUGH SL2 4HL,BERKS,ENGLAND

来源：

HISTOPATHOLOGY | 1990年 / 16卷 / 06期

关键词：

angiolymphoid hyperplasia; atopic reaction; Keywords; Kimura's disease; tetanus toxoid;

D O I：

10.1111/j.1365-2559.1990.tb01164.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Three cases of angiolymphoid hyperplasia with eosinophilia are reported at the site of tetanus toxoid vaccination. All presented as nodules on the upper arm, a known adverse effect of the vaccine following superficial inoculation. Histologically the nodules showed numerous small and medium sized vessels, some lined by hyperplastic endothelial cells with perivascular lymphocytic cuffing and an inflammatory infiltrate of plasma cells, eosinophils and scattered mast cells. Lymphoid follicles replete with germinal centres were identified in the dermis and subcutaneous tissue. Immunostaining revealed a polytypic lymphoplasmacytic infiltrate and a curious IgE reticulated pattern within the germinal centres, a feature described in both Kimura's disease and angiolymphoid hyperplasia. The present study suggests that atopic reaction to tetanus toxoid may be an aetiological factor in some cases of angiolymphoid hyperplasia. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：589 / 593

页数：5

共 21 条

[1] ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA INVOLVING SKELETAL-MUSCLE [J].