CHARACTERISTICS OF MOUSE TO RAT XENOGRAFT HEART-TRANSPLANTATION

被引：28

作者：

GANNEDAHL, G

FELLSTROM, B

LARSSON, E

ROOSENGSTRAND, E

TUFVESON, G

机构：

[1] UNIV UPPSALA,DEPT UROL,S-75105 UPPSALA,SWEDEN

[2] UNIV UPPSALA,DEPT INTERNAL MED,S-75105 UPPSALA,SWEDEN

[3] UNIV UPPSALA,DEPT PATHOL,S-75105 UPPSALA,SWEDEN

来源：

EUROPEAN SURGICAL RESEARCH | 1990年 / 22卷 / 04期

关键词：

15-Deoxyspergualin; Nude athmyic rat; Splenectomy; Xenograft; Xenotransplantation;

D O I：

10.1159/000129102

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A simple technique for grafting a mouse heart heterotopically to rat neck vessels in experimental xenotransplantation is described. In this series, graft survival was tested with the following modes of immunomodulation: ciclosporin (Cy), athymic and nude rats, splenectomy, total lymphoid irradiation (TLI), 15-deoxyspergualin in two different doses and various combinations of these. The mean graft survival time, with Cy or athymic and nude rats as recipients, was 3 days as also seen in animals without treatment. With either irradiation, splenectomy or 15-deoxyspergualin, 10 mg/kg daily, the graft survival time was prolonged to 7.8, 4.7 and 6.8 days, respectively. In combination, TLI + splenectomy gave a graft survival of 9.7 days and Cy + splenectomy 7.2 days. With 15-deoxyspergualin at 10 mg/kg/day plus splenectomy, done 1 week prior to transplantation, graft survival was extended to days. © 1990 S. Karger AG, Basel.

引用

页码：206 / 212

页数：7

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