INTRAVENOUS PROPOFOL ANESTHESIA USING A COMPUTERIZED INFUSION SYSTEM

被引:154
作者
WHITE, M [1 ]
KENNY, GNC [1 ]
机构
[1] UNIV GLASGOW,GLASGOW ROYAL INFIRM,DEPT ANAESTHESIA,8-16 ALEXANDRA PARADE,GLASGOW G31 2ER,SCOTLAND
关键词
Anaesthetics; intravenous; propofol; Equipment; computers; infusion pumps;
D O I
10.1111/j.1365-2044.1990.tb14685.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Propofol offers many advantages as a total intravenous anaesthetic agent compared with other agents. However, considerable experience is necessary in order to give an uncomplicated anaesthetic. A mathematical model which describes the pharmacokinetic behaviour of the drug was incorporated into a computerised delivery system which enables the anaesthetist to achieve and maintain a target blood concentration of propofol and to manipulate this at will. The system was used to provide general anaesthesia for 33 healthy patients who underwent general surgery. A strong statistical relationship was found between measured blood propofol concentrations and the corresponding computer predictions (y =−0.50+1.36x). No significant differences in this relationship were found between patients who breathed spontaneously (y =−0.71x+1.43x) and those who received intermittent positive pressure ventilation (y =−0.33+1.32x). Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:204 / 209
页数:6
相关论文
共 8 条
  • [1] DEGROOD PMRM, 1985, POSTGRAD MED J, V61, P65
  • [2] TOTAL INTRAVENOUS ANESTHESIA
    DUNDEE, JW
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 1978, 50 (02) : 89 - 90
  • [3] Gepts E, 1988, Anaesthesia, V43 Suppl, P8, DOI 10.1111/j.1365-2044.1988.tb09060.x
  • [4] LEMMENS HJM, 1988, ANAESTHESIA, V43, P850
  • [5] Roberts F L, 1988, Anaesthesia, V43 Suppl, P14, DOI 10.1111/j.1365-2044.1988.tb09061.x
  • [6] Schuttler J, 1988, Anaesthesia, V43 Suppl, P2, DOI 10.1111/j.1365-2044.1988.tb09059.x
  • [7] COMPUTER-CONTROLLED INFUSION OF PROPOFOL
    TACKLEY, RM
    LEWIS, GTR
    PRYSROBERTS, C
    BOADEN, RW
    DIXON, J
    HARVEY, JT
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 1989, 62 (01) : 46 - 53
  • [8] DOSE REQUIREMENTS OF PROPOFOL BY INFUSION DURING NITROUS-OXIDE ANESTHESIA IN MAN .2. PATIENTS PREMEDICATED WITH LORAZEPAM
    TURTLE, MJ
    CULLEN, P
    PRYSROBERTS, C
    COATES, D
    MONK, CR
    FAROQUI, MH
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 1987, 59 (03) : 283 - 287