STIMULATION OF BIOSYNTHESIS OF NERVE GROWTH-FACTOR BY ACIDIC FIBROBLAST GROWTH-FACTOR IN CULTURED MOUSE ASTROCYTES

被引：26

作者：

ONO, T ^{[1
]}

SAITO, H ^{[1
]}

KISHIMOTO, T ^{[1
]}

OKUMOTO, T ^{[1
]}

MIYAMOTO, K ^{[1
]}

机构：

[1] ASAKA PSYCHIAT INST,FUKUSHIMA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 01期

关键词：

ACIDIC FIBROBLAST GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR; NERVE GROWTH FACTOR; MESSENGER RNA; ASTROCYTE; PROLIFERATION;

D O I：

10.1016/0304-3940(91)90360-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bovine acidic and basic fibroblast growth factors (aFGF and bFGF) dose-dependently stimulated the release of nerve growth factor (NGF) in a culture medium of mouse astrocytes. The NGF concentration in the medium started to increase compared to that of the control cultures 4 h later and was further sustained for 24 h when aFGF was contained. The content of NGF mRNA in the astrocytes treated with aFGF peaked at eightfold over the control level after 4 h. The astrocytes did not proliferate until after 72 h when treated with FGFs under the conditions employed. These results indicate that aFGF stimulates the biosynthesis of NGF in cultured astrocytes without promoting cell proliferation.

引用

页码：18 / 20

页数：3

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