PROTECTIVE EFFECTS OF FELBAMATE AGAINST HYPOXIA IN THE RAT HIPPOCAMPAL SLICE

被引：52

作者：

WALLIS, RA

PANIZZON, KL

FAIRCHILD, MD

WASTERLAIN, CG

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, SCH LAW, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, SCH PHARMACOL, LOS ANGELES, CA 90024 USA

来源：

STROKE | 1992年 / 23卷 / 04期

关键词：

D O I：

10.1161/01.STR.23.4.547

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose: Felbamate is a new dicarbamate anticonvulsant with low toxicity currently being investigated in human clinical epilepsy trials. In this study, we examined the protective effects of felbamate against hypoxia. Methods: We exposed paired rat hippocampal slices to hypoxia with and without felbamate treatment while monitoring the CA1-evoked population spike. Results: Felbamate provided dose-dependent neuroprotection against hypoxia at concentrations of 45 mg/l and greater (p < 0.05). At a felbamate concentration of 300 mg/l, recovery of CA1 evoked population spike amplitude after hypoxic exposure was 99% compared with 0.5% for unmedicated paired slices. The appearance and disappearance of the hypoxic injury potential was delayed in slices treated with 300 and 400 mg/l (p < 0.05). Conclusions: In this model of hypoxia, felbamate provided neuroprotection against hypoxia at concentrations similar to serum felbamate levels currently being used in human clinical epilepsy trials.

引用

页码：547 / 551

页数：5

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