E-SELECTIN EXPRESSION IN SALIVARY ENDOTHELIAL-CELLS AND SERA FROM PATIENTS WITH SYSTEMIC-SCLEROSIS - ROLE OF RESIDENT MAST CELL-DERIVED TUMOR-NECROSIS-FACTOR-ALPHA

被引：49

作者：

HEBBAR, M ^{[1
]}

LASSALLE, P ^{[1
]}

JANIN, A ^{[1
]}

VANHEE, D ^{[1
]}

BISIAU, S ^{[1
]}

HATRON, PY ^{[1
]}

TONNEL, AB ^{[1
]}

GOSSELIN, B ^{[1
]}

机构：

[1] INST PASTEUR,INSERM,U416,F-59019 LILLE,FRANCE

来源：

ARTHRITIS AND RHEUMATISM | 1995年 / 38卷 / 03期

关键词：

D O I：

10.1002/art.1780380318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To assess endothelial cell activation in patients with systemic sclerosis (SSc). Methods, Concomitant study of salivary gland biopsy tissues and sera for expression of E-selectin and its potent activator tumor necrosis factor alpha (TNF alpha), using immunostaining and enzyme-linked immunosorbent essay, Results, E-selectin was overexpressed in SSc patients, but not in controls, TNF alpha was detected in mast cells, Conclusion. Mast cell-derived TNF alpha may contribute to endothelial cell activation in SSc.

引用

页码：406 / 412

页数：7

共 25 条

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