THE ROLE OF SEROTONIN AS A MEDIATOR OF EMESIS INDUCED BY DIFFERENT STIMULI

被引:11
作者
DUBOIS, A [1 ]
KRIESINGERSCHROEDER, H [1 ]
MEERPOHL, HG [1 ]
机构
[1] UNIV FREIBURG, FRAUENKLIN, D-79106 FREIBURG, GERMANY
关键词
VOMITING; 5-HYDROXYINDOLEACETIC ACID; (5-HIAA); PREGNANCY SICKNESS; MOTION SICKNESS; CHEMOTHERAPY;
D O I
10.1007/BF00335303
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this work was to evaluate the impact of changes in serotonin metabolism on the pathophysiology of different types of emesis: pregnancy-induced emesis, emesis associated with inner-ear dysfunction, and cisplatin-induced emesis. The urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin, was measured in 13 women with pregnancy-induced emesis, 12 patients who had nausea and vomiting following inner-ear dysfunctions, 27 patients with cisplatin-induced emesis and a control group of 21 women. 5-HIAA was measured with a fluorescence polarization immunoassay (Abbott) and corrected for varying urine concentrations. Both patients with emesis associated with inner-ear dysfunction and patients with pregnancy-associated emesis showed a similar 5-HIAA excretion pattern compared with the control group. No correlation between intensity of nausea or vomiting and changes in 5-HIAA excretion could be detected. Tn patients receiving cisplatin, the 5-HIAA excretion increased rapidly within the 12 h following cisplatin administration and returned to baseline levels after 24 h. There was a parallel increase of 5-HIAA excretion and numbers of emetic episodes in the first 12 h, but delayed emesis was not associated with elevated 5-HIAA excretion. Our results provide evidence that serotonin is involved in the pathophysiology of cisplatin-induced acute emesis. Cisplatin-induced delayed emesis, pregnancy-associated emesis, and emesis due to inner-ear dysfunction are not associated with elevated levels of 5-HIAA excretion. The serotonin pathway probably represents only one of many different afferent mechanisms capable of initiating the emesis cascade.
引用
收藏
页码:285 / 290
页数:6
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